Paramjit Arora

Professor of Chemistry
Phone: 212-998-8470
Office: Brown Building, 29 Washington Place, Room 360
Lab Homepage

Areas of Research/Interest
Bioorganic Chemistry and Chemical Biology

Research Description
Proteins often utilize small folded domains for recognition of other proteins, DNA and RNA. The hypothesis guiding our research is that by mimicking these folded domains we can modulate the function of a particular protein with metabolically stable synthetic molecules. The manifestation of this hypothesis into specific and potent compounds that interfere with chosen targets in cellular and animal systems requires new computational and synthetic approaches. We seek to devise a systematic framework to evaluate and target protein-protein interactions with structured peptidic and nonpeptidic scaffolds designed to reproduce the critical interfacial features of proteins.

Lao, B. B.; Drew, K.; Guarracino, D.; Brewer, T.; Heindel, D.; Bonneau, R.; Arora, P. S. “Rational Design of Topographical Helix Mimics as Potent Inhibitors of Protein-Protein Interactions.” J. Am. Chem. Soc. 2014, 136, 7877–7888.

Lao, B. B.; Grishagin, I.; Mesallati, H.; Brewer, T. F.; Olenyuk, B. Z.; Arora, P. S. “In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics.” Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 7531–7536.

Miller, S. E.; Watkins, A. M.; Kallenbach, N. R.; Arora, P. S. “Effects of side chains in helix nucleation differ from helix propagation.” Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 6636-6641.

Kushal, S.; Lao, B. B.; Henchey, L. K.; Dubey, R. Mesallati, H.; Traaseth, N. J.; Olenyuk, B. Z.; Arora, P. S. “Protein Domain Mimetics as In Vivo Modulators of Hypoxia-Inducible Factor Signaling.” Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 15602-15607.

Patgiri, A.; Joy, S. T.; Arora, P. S. “Nucleation Effects in Peptide Foldamers.” J. Am. Chem. Soc. 2012, 134, 11495-11502.

Bullock, B. N.; Jochim, A. L.; Arora, P. S. “Assessing Helical Protein Interfaces for Inhibitor Design.” J. Am. Chem. Soc. 2011, 133, 14220-14223.

Patgiri, A.; Yadav, K.; Arora, P. S.; Bar-Sagi, D. “An Orthosteric Inhibitor of the Ras–Sos Interface.” Nature Chem. Biol. 2011, 7, 585-587.

Jochim, A. L.; Arora P. S. “Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors.” ACS Chem. Biol. 2010, 5, 919-923.

Wang, D.; Liu, J.; Zheng, Q.; Lu, M.; Arora, P. S. “Atomic Structure of a Short Alpha-Helix Stabilized by a Main Chain Hydrogen Bond Surrogate”. J. Am. Chem. Soc. 2008, 130, 4334-4337.

Wang, D.; Lu, M.; Arora, P.S. “Inhibition of HIV-1 Fusion by Hydrogen-Bond Surrogate Based Alpha-Helices.” Angew. Chem. Int. Ed. 2008, 47, 1879-1882.

American Cancer Society Postdoctoral Fellowship (1999-2002), James D. Watson Investigator Award (2002), Cottrell Scholar Award (2005), Whitehead Fellowship in Biomedical and Biological Sciences (2005-2006), Golden Dozen Teaching Award (2007)

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