Nicholas E. Geacintov

Professor of Chemistry
B.S. (physical and polymer chemistry), SUNY; M.S. (physical and polymer chemistry) Syracuse; Ph.D. (physical and polymer chemistry) Syracuse; Postdoctoral research at Brooklyn Polytechnic Institute

Email:
Phone: 212-998-8407
Office: Brown Building, 29 Washington Place, Room 453C
Lab Homepage

Areas of Research/Interest
The overall objective is to understand the mechanisms and consequences of damage in DNA, either free or wrapped around histone octamers in nucleosomes, induced by environmental contaminants and other reactive chemical species employing well defined model systems.

Publications
Reeves DA, Mu H, Kropachev K, Cai Y, Ding S, Kolbanovskiy A, Kolbanovskiy M, Chen Y, Krzeminski J, Amin S, Patel DJ, Broyde S, Geacintov NE. Resistance of bulky DNA lesions to nucleotide excision repair can result from extensive aromatic lesion-base stacking interactions.  Nucleic Acids Res. 2011, 39(20): 8752-64.

Liu Y, Reeves D, Kropachev K, Cai Y, Ding S, Kolbanovskiy M, Kolbanovskiy A, Bolton JL, Broyde S, Van Houten B, Geacintov NE.  Probing for DNA damage with β-hairpins: Similarities in incision efficiencies of bulky DNA adducts by prokaryotic and human nucleotide excision repair systems in vitro. DNA Repair (Amst), 2011, 10(7):684-96.  

Hendel A, Krijger PH, Diamant N, Goren Z, Langerak P, Kim J, Reissner T, Lee KY, Geacintov NE, Carell T, Myung K, Tateishi S, D'Andrea A, Jacobs H, Livneh Z.   PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells.  PLoS Genet. 2011 Sep; 7(9):e1002262.

Lee YA, Liu Z, Dedon PC, Geacintov NE, Shafirovich V. Solvent Exposure Associated with Single Abasic Sites Alters the Base Sequence Dependence of Oxidation of Guanine in DNA in GG Sequence Contexts. ChemBiochem. 2011, 12(11):1731-9.

Cai Y, Wang L, Ding S, Schwaid A, Geacintov NE, Broyde S. A bulky DNA lesion derived from a highly potent polycyclic aromatic tumorigen stabilizes nucleosome core particle structure. Biochemistry, 2011 23;49(46):9943-5.  

Shao J, Geacintov NE, Shafirovich V. Oxidative modification of guanine bases initiated by oxyl radicals derived from photolysis of azo compounds. J Phys Chem B. 2010, 114(19):6685-92. PMID: 20415485.

Rechkoblit O, Kolbanovskiy A, Malinina L, Geacintov NE, Broyde S, Patel DJ.  Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine  lesion by Y-family polymerase Dpo4. Nature  Struct Mol Biol. 2010 (3):379-88.

Liang J, Zhang J, Zhu L, Duarandin A, Young VG, Geacintov N, Canary JW. Structures, metal ion affinities,  and fluorescence properties of soluble derivatives of tris((6-phenyl-2-pyridyl)methyl)amine. Inorg Chem.  2009, 48(23): 11196-208.

Ziv O, Geacintov NE, Nakajima S, Yasui A, and Livneh Z.  DNA polymerase Zeta cooperates with polymerase Kappa and Iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients. Proc Natl Acad Sci USA  (2009) 106(28):11552-7.

Geacintov, N.E. and Broyde, S., Eds. (2010). The Chemical Biology of DNA Damage.  Wiley-VCH Verlag GmbH, Weinheim, Germany (449 pages).

External Affiliations
American Chemical Society, American Physical Society, American Association for the Advancement of Science, American Association for Cancer Research, Russian Academy of Sciences

Fellowships/Honors
President, American Society for Photobiology, 1994, 1995; Foreign Member, Russian Academy of Sciences, 1994; Fellow, American Physical Society, 1978; Fellow of the American Chemical Society, 2010. Margaret and Herman Sokol Faculty Award for Excellence in the Sciences, 2007 (NYU).

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